{"id":7517,"date":"2021-02-11T07:20:00","date_gmt":"2021-02-11T06:20:00","guid":{"rendered":"https:\/\/xd3kj9bvqee.preview.infomaniak.website\/?p=7517"},"modified":"2021-02-11T00:51:11","modified_gmt":"2021-02-10T23:51:11","slug":"silab-develops-a-3d-model-mimicking-skin-acne","status":"publish","type":"post","link":"https:\/\/www.industries-cosmetiques.fr\/en\/silab-develops-a-3d-model-mimicking-skin-acne\/","title":{"rendered":"Silab develops a 3D model that mimics acne-prone skin"},"content":{"rendered":"

Silab Softcare's advanced research teams have developed a 3D model of reconstructed epidermis that mimics in vitro <\/em>acneic skin. The characterization of this model has just been published by the scientific journal Experimental Dermatology<\/em>*.<\/p>\n\n\n\n

Acne is an inflammatory skin disease involving four essential components: hyperseborrhea combined with a change in sebum composition, colonization by Cutibacterium (C.) acnes<\/em> and in particular the virulent phylotype IA1, hyperkeratinization and secreted inflammation.<\/p>

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Most 3D models mimicking acneic skin independently use hyperseborrhea or invasion by C. acnes<\/em> to induce the different characteristics of acneic skin. However, as these two factors are dependent on each other in the early stages of the pathology, the aim of this study was to develop a 3D model combining sebum alteration and invasion by C. acnes<\/em>.<\/p>\n\n\n\n

Thus, a reconstructed epidermis was treated with peroxidized squalene and the IA1 phylotype of C. acnes<\/em>The combination of these two factors allowed the induction of acne-related keratinocyte responses such as hyperkeratinization and inflammation. The combination of these two factors allowed the induction of keratinocyte responses related to acne such as hyperkeratinization and inflammation, and thus obtaining a model with all the characteristics of acneic skin.<\/p>\n\n\n\n

\"The extensive characterization of this new model <\/em>in vitro has proven that it is fully adapted to mimic acne-prone skin and serve as a screening tool for the development of anti-acne treatments.<\/em>says Marine Laclaverie, Innovation Project Manager in vitro<\/em>Silab.<\/p>\n\n\n\n

Acnesium, the daily care for acne-prone skin<\/strong><\/p>\n\n\n\n

The 3D model obtained during this study has allowed to demonstrate the pharmacological activities of Acnesium, a natural active ingredient developed by Silab Softcare to treat the clinical signs of mild to moderate acne in adults.<\/p>\n\n\n\n

Produced from immature pomegranate bark, Acnesium restores homeostasis to acne-prone skin by targeting the four major components of this pathophysiology: it normalizes sebaceous gland activity, controls colonization by the IA1 phylotype of C. acnes<\/em>It has a keratolytic action and reduces inflammation. Combining speed of action and effectiveness, this high-tolerance treatment improves the general appearance of the skin and thus the quality of life of patients.<\/p>\n\n\n\n

* Laclaverie et al, Development and characterization of a 3D in vitro model mimicking acneic skin, Experimental Dermatology<\/em> (https:\/\/doi.org\/10.1111\/exd.14268) Experimental Dermatology; Impact factor 3.368; Ranking 15\/146 in Dermatology<\/sub><\/p>","protected":false},"excerpt":{"rendered":"

Les \u00e9quipes de recherche avanc\u00e9e de Silab Softcare ont mis au point un mod\u00e8le 3D d\u2019\u00e9piderme reconstruit mimant in vitro la peau acn\u00e9ique. La caract\u00e9risation de ce mod\u00e8le vient d\u2019\u00eatre publi\u00e9e par le journal scientifique Experimental Dermatology*. L\u2019acn\u00e9 est une maladie inflammatoire cutan\u00e9e impliquant quatre composantes essentielles : une hyperseborrh\u00e9e combin\u00e9e \u00e0 une modification de […]<\/p>\n","protected":false},"author":148,"featured_media":7518,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"external_url":"","footnotes":""},"categories":[51],"tags":[60],"class_list":{"0":"post-7517","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-ingredients","8":"tag-info-produit"},"acf":{"nc":"e.lasjaunias@silab.fr","nc2":"communication@silab.fr","nc3":"","nc4":"","nc5":"","nom_url":"silab.fr","lien_url":"https:\/\/www.silab.fr"},"_links":{"self":[{"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/posts\/7517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/users\/148"}],"replies":[{"embeddable":true,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/comments?post=7517"}],"version-history":[{"count":0,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/posts\/7517\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/media\/7518"}],"wp:attachment":[{"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/media?parent=7517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/categories?post=7517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.industries-cosmetiques.fr\/en\/wp-json\/wp\/v2\/tags?post=7517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}