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Cerebiome focuses on the intestine-brain-skin axis

Lallemand Health Solutions recently announced the latest results of a study on Cerebiome, a psychobiotic developed by Institut Rosell, its research and development center for the microbiome and probiotics. This innovative formula combines two probiotic strains, Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175has shown significant benefits for occasional stress, sleep quality and skin appearance.

The open clinical study, supervised by a dermatologist, investigated the effects of Cerebiome on 35 healthy Caucasian women aged between 30 and 45 over an eight-week period. Participants took 3 billion CFU (colony-forming units) of Cerebiome once a day.

Reduced perceived stress and benefits for sleep

The primary outcome measured was perceived stress using the PSS-10 on days 28 and 56. According to Lallemand Health Solutions, the study revealed a significant reduction in perceived stress, with a decrease of 18 % after four weeks and 31 % after eight weeks. In addition, 79 % of participants reported significant improvements in their mental well-being.

Secondary results from the study also showed improvements in sleep quality. Participants noted a marked improvement in their ability to fall asleep and stay asleep, as well as a reduction in difficulties staying awake during the day.

Benefits for skin appearance

In terms of skin appearance, Lallemand Health Solutions has shown that Cerebiome contributes to hydration, firmness and a reduction in the appearance of wrinkles, fine lines and skin tone. There was a significant increase in skin hydration, with an improvement of 21 % on the face after eight weeks and up to 18 % on the body. In addition, 85 % of women reported that their skin was more hydrated and nourished. The study also showed significant improvements in skin tone, firmness and elasticity, with a 12 % increase in skin firmness after eight weeks of taking Cerebiome. The Cosmebiome study also showed significant improvements in reducing the appearance of fine lines and wrinkles. 

After just four weeks of taking Cerebiome, participants saw a 7 % reduction in the appearance of facial wrinkles, then 17 % after 8 weeks. The forehead area showed even more pronounced results, with a reduction of 12 % after 4 weeks and 21 % after 8 weeks. What's more, 82 % of women reported smoother skin and improved texture, demonstrating Cerebiome's impact on improving overall skin appearance, texture and tone.

The rise of nutricosmetics

Elodie Aragon, Product Manager at Lallemand Health Solutions, details the potential impact of this study for the nutricosmetics market: "We are delighted to share the results of our latest study on Cerebiome. This psychobiotic not only supports intestinal and mental well-being, but also significantly improves skin health, offering a holistic approach to beauty and well-being. There is great potential for nutricosmetics brands, as the market is valued at $8.09 billion in 2023 and is expected to reach $11.91 billion by 2028, with an annual growth rate of 8 %."

Probiotics offer a promising route to maintaining overall wellbeing and having a positive impact on skin health, with 66 % of people recognizing the link between skin health and overall wellbeing.

Applications and methods of use

The formula is available in a variety of dosage formats, including soluble powders, orodispersible powders, capsules, sticks, sachets and more. It can be formulated with ingredients such as riboflavin (vitamin B2) and folic acid (vitamin B9) for skin stress and anti-aging, vitamin B6 for stress/mood and skin balance, melatonin and vitamin B6 for sleep and skin balance, and vitamin C and copper for energy and glowing skin. Cerebiome and other documented strains can support beauty claims in Europe. From lab to counter, Lallemand Health Solutions has the total control and expertise to produce top-quality custom probiotic formulations in state-of-the-art facilities certified for the highest quality.

Formula claims are based on scientific strain data and local regulations.

The Lallemand Health Solutions team will be present at in-cosmetics global, to be held in Amsterdam, the Netherlands, from April 8 to 10, 2025.

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