A precursor in the field of mechanobiology since 2007, Coheliss is a firming, anti-gravity active ingredient developed by Silab to stimulate the skin's mechanical and biological cellular functions, in response to mechano-stress. It acts specifically on sagging skin, a major concern for consumers.
Additional efficacy data in vitro in 2016 confirm its ability to act on mechanobiology, a central process in maintaining skin firmness, by stimulating its three pillars: mechano-sensation, mechano-transduction and mechano-response.
Its firming action has been demonstrated with the help of modelling in vivo developed to measure skin response, with or without mechanical stress, in key areas of the face. After 28 days of twice-daily applications, and compared to placebo, the ingredient dosed at 3% improved skin's ability to return to its initial state by 12.6%. At 4%, skin tone increased significantly by 19% (p < 0.05) and skin tension by 16% (p < 0.05).
Through its smoothing and anti-wrinkle effect, Coheliss limits the appearance of gravitational folds and expression lines. The total surface area of wrinkles in crow's feet and the nasolabial fold was reduced by 15% and 26% respectively (p < 0.01) (Results after 56 days of twice-daily application, compared with placebo).
A combination of firmness and anti-gravity, Coheliss is positioned as a biomimetic active ingredient by transposing to the skin the natural properties of arabinoxylans, the molecules responsible for rye's cohesion and mechanical strength.
