Seppic presents Subligana, an anti-blemish active ingredient

Seppic launches Subligana, a new active ingredient against blemishes and pimples, for a zero-defect effect linked to oxidative stress, an active ingredient created by Serdex, a Seppic subsidiary since January 2017.

Acne affects almost 80% of the population at some point in their lives( 1) . New studies show that increased oxidative stress at both systemic and cutaneous levels is involved( 2) .
Subligana is a titrated extract of Harungana madagascariensis from central and eastern Madagascar. By acting as a repellent and physical barrier, Harungana madagascariensis is able to protect primary forests from external aggression and restore degraded environments. Botanists call it the "Protector of the forest". Traditionally, leaf decoctions are used for asthma and skin problems, and leaf juice is used as a healing agent.
This new active ingredient is designed for acne-prone skin with imperfections. A use test on teenagers with acne-prone skin showed a significant reduction in the number of whiteheads versus placebo after 28 days. Subligana's mode of action combines a soothing effect (inhibition of lipase, regulation of IL-10 & IL-12), an antioxidant effect (protection against lipid peroxidation) and an effect against Propionibacterium acnes .
Harungana madagascariensis leaves are collected according to good collection practices in the highlands of Madagascar to ensure a reproducible phytochemical composition. Serdex has set up a sustainable and ethical supply chain committed to the fair and ethical sharing of benefits in accordance with the Nagoya Protocol.