A new paper, published in the International Journal of Molecular Sciences, has concluded that Bioiberica's Dermial ingredient - the first hyaluronic acid-based matrix ingredient for skin and beauty - exhibits anti-aging, regenerative and antioxidant properties in skin cells. The peer review confirms Dermial's promising potential in developing cutting-edge products for the growing nutricosmetics space - creating exciting opportunities for brands in the dietary supplements, functional foods and cosmetics sectors.
Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), are an important component of the skin's extracellular matrix, and have been shown to maintain skin hydration and regulate cell migration, proliferation and differentiation. With age, GAGs decline, as do the concentration and quality of dermal collagen and elastin, resulting in a loss of skin hydration, dermal thickness and healthy appearance. The study aimed to extract, characterize and evaluate the benefits of Bioiberica's hyaluronic acid matrix ingredient, Dermial, at an in vitro level, for skin and beauty innovation.
The results of the study showed that Dermial has a high concentration of hyaluronic acid (67 %) and is also composed of other GAGs, such as dermatan sulfate, and collagen. In vitro evaluation of the ingredient's biological activity in keratinocytes and fibroblasts showed that it induced cell proliferation and migration, and increased the synthesis of type I and III collagen, elastin and GAGs. This suggests that it has moisturizing, regenerative and anti-aging properties. The study also revealed Dermial's antioxidant properties in skin cells - the first time the ingredient's protective role against oxidative stress has been demonstrated. In addition, the hyaluronic acid matrix ingredient is readily absorbed in the gut, indicating that it could be used in oral and topical skin care applications.
Dermial is a hyaluronic acid-based matrix solution backed by science, but with a difference. Its unique combination of three natural components - hyaluronic acid, other GAGs such as dermatan sulfate and collagen - works synergistically to nourish the skin at a low dose of 60 mg/day. In addition to the promising results mentioned above, Dermial has demonstrated a superior effect to that of pure hyaluronic acid of fermentary origin, a well-known ingredient in skin care.
" The findings of this latest peer-reviewed article mark an exciting development in Dermial research - further verifying the scientific benefits of the ingredient and its potential in nutricosmetics "says Daniel Martínez Puig, Head of Human Health R&D, Bioiberica. " We look forward to opening up exciting prospects for brands already present in this market or considering entering it. Following these promising results, our next step will be to conduct a clinical trial to confirm Dermial's efficacy in humans.".
Antonio Vendrell, Bioiberica's Marketing Director, adds: " The "beauty from the inside out" market has grown rapidly in recent years, fueled by growing consumer interest in general wellbeing, the holistic health movement and the realization that beauty can be achieved from the inside out through nutrition. Many consumers are taking a more proactive approach to their skin's health, making them more inclined to try nutritional solutions, including ingestible beauty products. This has created a new space for new ingredients, such as Dermial - our hyaluronic acid-based matrix ingredient.".