Due to environmental factors and age, the skin loses its ability to regenerate, weakening the skin barrier and dermal architecture.
In response to this observation, Silab developed Glyco-Repair in 2008, a natural active ingredient capable of reactivating the skin's natural repair processes. In 2020, Silab brings additional efficacy data to its active ingredient in the context of aging:
- In the epidermis, by confirming the ability of Glyco-Repair to reactivate the various biological pathways involved in re-epithelialization, in particular keratinocyte differentiation, and by highlighting its healing action [1];
- In the dermis, by reaffirming the ability of Glyco-Repair to restore the integrity of the support tissue, in particular through its action on the architecture of the dermal matrix and the functionality of the fibroblasts [2].
Repairing actions on the dermis and epidermis
As early as 2008, the ability of Glyco-Repair to repair skin tissue quickly and intensely following an aggression had, according to Silab, been demonstrated.
New efficacy data show that the active ingredient also repairs age-related disorders. Indeed, a fringe projection study shows that Glyco-Repair, tested at 3 % for 14 days of twice-daily application on a mature Caucasian panel, improves skin microrelief, particularly the Sa parameter (-8.6 %). In addition, after 28 days of twice-daily application, clinical scoring by experts on digital photographs showed that the appearance of pores was reduced (-13.8 %) and that crow's feet wrinkles were reduced (-10.5 %).
A self-assessment by the volunteers confirms these data, since 83 % of them perceive their skin texture as refined and 94 % note smoother skin and less visible wrinkles and fine lines.
To support its concept of tissue regeneration, Silab has chosen a natural raw material with restorative properties: the carob tree (Ceratonia siliqua). Its rusticity and its ability to adapt to environmental constraints are indeed appreciated for restoring degraded ecosystems.
Carob seeds with regenerative properties
Silab has been particularly interested in carob seed gum and has joined forces with two partners on the island of Majorca (one for harvesting the carobs, the other for processing them into gum), the aim being to ensure traceability from the plot and to control quality. A controlled process of enzymatic hydrolysis allowed Silab to extract oligogalactomannans with a unique average degree of polymerization (DP = 17), responsible for the effectiveness of the active.
Glyco-Repair is a patented active ingredient, of natural origin at 99.3 % (ISO 16128) and respecting the regulations on biodiversity. Available in aqueous solution (recommended dose: 1 to 3 %), it complies with international cosmetic regulations (Europe, USA, Japan, China, etc.).
[1] Tested at 0.5% on injured Silabskin RE reconstructed epidermis, Glyco-Repair improves wound repair by +98 %.
[2] Tested at 0.5% on human fibroblasts from young and aged donors, Glyco-Repair increases collagen I network synthesis by +64 %.
