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Support for biotic rejuvenation: BASF's Care Creations launches skin care ingredients based on bacteria found in young skin.

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Probiolift: The first cosmetic ingredient containing a live probiotic helps to give the skin a fuller appearance and improve the appearance of forehead wrinkles.

Postbiolift: the postbiotic makes the skin more elastic, smoothes the appearance of crow's feet wrinkles and gives the impression of an even complexion.

Cosmetic ingredients exploit Lactobacillus crispatus bacteria that are abundant in young skin and significantly decreased in older skin

With Probiolift and Postbiolift, CARE CREATIONS from BASF presents two new biotic ingredients that promote healthy and harmonious skin aging. Unlike other biotics on the cosmetics market, the newly developed ingredients are the first to use a bacterium found naturally in the skin: Lactobacillus crispatus (L crispatus), an anaerobic Gram-positive rod bacterium that has been found to decrease with age.

"Consumers are increasingly aware of the health benefits of biotic ingredients, whether pre, pro or postbiotic. This trend has its origins in the food industry," said Cécile Kalem, head of BASF's active ingredients launch in Europe. What is common practice in this area has been, so far, one of the most challenging tasks for the personal care industry: incorporating live skin bacteria into cosmetic formulations and keeping them active. With Probiolift, we have found a solution to this challenge – a real breakthrough for our research and development teams."

New insights into changes in the facial microbiome during aging

In addition to existing research that indicates that the diversity of the skin microbiota changes with age, BASF has conducted a new study on the difference in facial microbiome composition of young and old people. The research team found that lactic acid bacteria, including Lactobacilli, decrease noticeably in mature skin. The species L. crispatus, in particular, decreased in the subocular area and was not detectable in the hollow of the wrinkles of older volunteers. This discovery led BASF researchers to speculate that L. crispatus, isolated from human skin, could be the key to younger-looking skin. BASF has developed two cosmetic ingredients from the same biofermentation process: Probiolift, the probiotic with dormant cells of living L crispatus, and Postbiolift, the fermentation supernatant containing the metabolites secreted by L. crispatus.

Probiolift™ for fuller skin with a reduction in the appearance of wrinkles.

Probiolift is composed of live but dormant L. crispatus bacteria that wake up in contact with water on the skin. The ingredient thus unlocks a hitherto largely untapped potential in the biotic beauty sector. It promotes harmonious skin aging by giving the skin a fuller appearance and improving the appearance of forehead wrinkles.

Twenty-nine female volunteers aged 45 to 65, who had fine lines or wrinkles on their foreheads, participated in the clinical study. The efficacy of a base cream containing 0.05% Probiolift was evaluated compared to a placebo base cream. The Probiolift allowed the volunteers' skin to appear fuller after two months. Although the appearance of forehead wrinkles is more difficult to mitigate than that of crow's feet, the new probiotic offered a visible correction in this area as well, allowing for a 5% reduction in the appearance of wrinkles compared to placebo. The clinical results were supported by the biological properties of L crispatus demonstrated in advanced in vitro tests.

Postbiolift for more elastic, smooth and even looking skin

Postbiolift is a unique new postbiotic ingredient containing beneficial metabolites secreted by L. crispatus. It helps to improve the mechanical properties of the skin in order to make it more elastic, smooth the appearance of wrinkles around the eyes and create an even complexion appearance.

The efficacy of Postbiolift was demonstrated in a placebo-controlled clinical study of 30 female volunteers aged 40 to 50 years with crow's feet wrinkles and colour spots on the face. After 28 days and 56 days of treatment with the ingredient formulated at 1% in a cream, the elastic parameters were evaluated. The results were significant compared to placebo, with an improvement of up to 10 percent.

In addition, by the end of the 56-day study, Postbiolift had significantly reduced the appearance of crow's feet and pigmented age spots in these middle-aged women by almost 7% compared to placebo. The mechanism underlying the observed clinical outcomes has been demonstrated by comprehensive in vitro studies.

Together, these two new ingredients enable cosmetics manufacturers to meet the growing demand for clinically proven biotic products that promote skin youth.

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