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Tuesday December 6th, 2022
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Gattefossé & CTIBiotech develop the first connected chip to measure bio impedance in bio-printed 3D skins

Sebum is a complex mixture of lipids secreted by sebocytes and deposited in the stratum corneum to contribute to the barrier function of the skin. Disruption of sebum production is associated with skin conditions, including acne or atopic dermatitis; it also affects the appearance and beauty of the skin by contributing to the development of oily or dry skin.

The in vivo confirmation of the efficacies obtained in vitro in healthy volunteers remains a critical step with a high failure or disappointment rate. This is why cosmetic laboratories continue to search for the most relevant biological markers and to develop in vitro testing methods that are fast, easy to implement, robust and, ultimately, as predictive as possible.

Gattefossé and CTIBiotech have joined forces to develop a bio-printed 3D model of skin incorporating sebocytes to measure, at the same time, non-invasive in vitro parameters easily applicable to in vivo measurements and experimental laboratory data.

Bio impedance (or bioelectric impedance analysis) has long been used to track the evolution of our body's fat mass and thus make it a personalized indicator for monitoring our health at home (scales). Using connected tools, Gattefossé and CTIBiotech used bio impedance to assess changes in the local environment of a 3D skin model incorporating sebocytes. The measurement of such non-invasive electrical activity made it possible to monitor sebum production in real time, in parallel with laboratory analyses related to the cellular, matrix and tissue development of the model.

Bio impedance has long been used in our weights and by dieticians to understand the general composition of the body. The application of this technique to the skin is an obvious step forward, but the real innovation lies in the development of real-time analysis of sebum changes. We have perfected our 3D printed complete skin models with a built-in bio impedance chip connected to monitor changes. By linking the screening of cosmetic products in this way, we are moving faster towards human testing and increasing our ability to manufacture more efficient products," explainsProf. Colin McGuckin, President and Chief Scientific Officer, CTIBiotech

Skin models containing sebocytes have reproducible sebum production, which is increased by linoleic acid and decreased by Tofa. This is characterized by significant changes in bio impedance both in the printed tissues and in the culture supernatants that surround them. Bio impedance, linked to the production of sebum, is therefore proving to be a clean non-invasive parameter in vitro and measurable in real time, to design ever more predictive and effective tests: indeed, the 3D models described here and connected to a simple chip system, accurately reflect changes in skin models as well as on living donors, "explains Dr. Nicolas Bechetoille, Ph.D/HDR – Head of R&D skin biology, Gattefossé

This work will be presented at 32th IFSCC Congress in London, 19-22 September 2022

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