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Givaudan Active Beauty unveils Zanthalene, an active ingredient that mimics the properties of botox

Givaudan Active Beauty presents Zanthalene, a natural modulable active ingredient developed by green fractionation, with botox-like efficacy in modulating skin sensitivity. Created from Zanthoxylum bungeanumZanthalene, commonly known as Sichuan pepper, is a cosmetic ingredient derived from the spice and capable of acting on neuromuscular communication within the skin structure, offering aging effects and soothing benefits depending on its concentration in formulas.

All consumers eventually experience the effects of aging on the skin, such as wrinkles and sensitivity. However, many do not wish to reverse these effects through invasive treatments. 

According to a study conducted on behalf of Givaudan Active Beauty186 % of consumers are interested in beauty products containing natural ingredients that help soothe skin discomfort while smoothing it out for a botox-like effect.

Giada Maramaldi, category manager for personal care at Givaudan, said: " Each facial expression activates a large number of muscles. Over time, as collagen production declines, these expressions become even more pronounced and embedded in the skin, leading to the formation of wrinkles. To combat these effects, Zanthalene offers a neurocosmetic strategy that relaxes facial muscles in a safe, reversible and natural way, adding a feeling of comfort while eliminating skin discomfort."

Made from Sichuan pepper, a plant widely used as a spice in Asian cuisine, Zanthalene is extracted from its fruit husks using supercritical CO2. Givaudan Active Beauty claims that its efficacy has been proven in several clinical studies: at low doses (0.5 %), Zanthalene is able to reduce skin discomforts such as itching and sensitivity, bringing a soothing effect to the skin in just a few minutes.

At a higher dosage (1 %), Zanthalene shows an immediate, visible reduction in skin roughness parameters in just 30 minutes, and long-term efficacy over 30 days. The body continues to react even after regular use of the product, creating a virtuous circle of improvement.

According to Givaudan Active Beauty, zanthalene is therefore a perfect ingredient for the formulation of beauty products targeting tired skin, aiming for a refreshed appearance and an immediately visible effect.

With over 80 % of consumers willing to buy a concept formulated with botox-like active ingredients, the brand's experts came up with an inspiring marketing concept: Sensilift, a cream based on Zanthalene. Thanks to Vetivyne, Centerox and rose seed oil, which regenerate and plump the skin, this highly natural anti-aging cream is also enriched with Jambu, which energizes the skin and provides a stimulating, moisturizing, comforting and soothing effect.

1 Zanthalene, Global online survey - Givaudan Active Beauty - May 2021

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