Algophagyl is a new, energizing natural active ingredient capable of preserving mitochondrial balance and function, restoring radiance and vitality to the skin.
The mitochondrion is the sole generator of cellular energy. Chronic or acute stress can cause it to malfunction, with deleterious effects on the skin.
With Algophagyl, Silab offers an innovative active ingredient that acts on three mitochondrial defense levers:
- mitochondrial quality control ;
- mitochondrial dynamics ;
- mitophagy.

In good health, mitochondria produce the energy needed for cell renewal and the establishment of a dynamic, effective skin barrier.

After 28 days of twice-daily applications and compared to placebo, Algophagyl brightened the skin of Caucasian and Asian volunteers, with a significant increase in L* and ITA° parameters, characteristic of lighter, brighter skin.
In addition to brightening the skin, the active ingredient also acts on the complexion's radiance.
After 14 days of twice-daily applications and in comparison with placebo, Algophagyl formulated at 2% in emulsion :
- improves skin radiance by 5.3% ;
- revives the pink color, characteristic of a fresh complexion, of 7.7% ;
- decreases olive color by 6.1% ;
- reduces eye fatigue by 7.1%.
This effect continues after 28 days of application.
A subjective evaluation by volunteers confirms these data: 100% of them find their skin revitalized, brighter and more supple.

Because microalgae are the origin of life, Silab's research has focused on their metabolic and adaptogenic properties to protect mitochondria.
Rich in glucans and galactans, Algophagyl (INCI name : Chlorella sorokiniana Extract) is derived from the microalgae Chlorella sorokinianaproduced industrially in Silab's biotechnology unit. Growing this microalgae heterotrophically, i.e. in the absence of light, requires it to synthesize specific molecules of interest with high added value.
Obtained through a non-denaturing manufacturing process, Algophagyl is a patented active ingredient, available in aqueous solution (recommended dose: 0.5 to 2%), and compliant with the main cosmetics regulations (Europe, United States, Japan).

The work of Silab's advanced research department and Dr Florence Ruggiero's* research team on dermal segmentation and its matrisome has been recognized by the international scientific community with the publication of a letter to the editor in the Journal of Investigative Dermatology (JID).

A major scientific discovery on the papillary and reticular dermis

The upper dermis, known as the papillary dermis, and the deeper dermis, known as the reticular dermis, are structurally and functionally different. Fibroblasts, the cells responsible for extracellular matrix synthesis, are thought to be at the origin of this segmentation.
"Segmentation of the dermis is a biological research signature dear to Silab " says Brigitte Closs, Executive Vice President, Research and Development, Silab. "When we started working on this subject in 2007, we naturally approached Dr Florence Ruggiero, CNRS Research Director, and her collaborators, recognized worldwide for their expertise in extracellular matrix biology."
Dr Florence Ruggiero's research team and the Silab advanced research department have demonstrated for the first time the signature of a specific gene expression in papillary and reticular fibroblasts in relation to the matrisome, defined as the set of genes coding for extracellular matrix proteins and its associated proteins.
"This letter to the editor in one of the most prestigious scientific dermatology journals is indisputable recognition of the quality of the research work carried out by the two teams. It reinforces our expertise in this field and opens up new prospects for the development of innovative, high-performance natural cosmetic solutions, particularly in the fight against skin ageing. It could also have bioengineering repercussions of skin substitutes to make them ever closer to the physiological reality of the skin." concludes Brigitte Closs.