University of San Diego and Silab unveil their discoveries on the microbiota of fragile skins

University of California at San Diego - University of San Diego

In 2019, Silab established a research partnership with Dr. Richard Gallo, a specialist in cutaneous microbiota in San Diego (UCSD, University of California San Diego), to further scientific knowledge on the role of the cutaneous microbiota in the inflammation processes characteristic of fragile skin. This work is currently the subject of two publications in the prestigious journals Cell Reports and The Journal of Allergy and Clinical Immunology.

The involvement of the cutaneous microbiota, in particular that of pathogenic opportunistic bacteria such as Staphylococcus aureus (S. aureus), in skin pathologies is no longer to be demonstrated. More recently, studies have reported an over-representation of Staphylococcus epidermidis (S. epidermidis) in lesional areas of weakened skin. This common commensal bacterium of the host beneficial and healthy microbiota may be involved in the compromised skin phenotype.

The objective of the work carried out by Dr. Gallo's team was to identify the role and mechanism of action of the two species S. aureus and S. epidermidis in the pathogenesis of two inflammatory skin diseases: Netherton syndrome and atopic dermatitis.

The results obtained confirm the existence of the pathogenic role of S. epidermidis in weakened skin, similar to S. aureus. The deleterious effects of these two species result from interspecies communication via the intelligent quorum sensing system. This system allows the synchronization of the secretion of proteases specific to each of the two bacterial populations. These virulence factors exacerbate the disruption of the barrier function and the inflammatory phenomenon characteristic of Netherton syndrome and atopic dermatitis.

Laura Cau, who participated in the UCSD project as part of a VIS (Volontariat international scientifique) funded by Silab, says: "These findings highlight the major influence on skin health of interspecies communication within the epidermal ecosystem. They reinforce the understanding of the role of the commensal microbiota in the development of inflammatory skin pathologies. »