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The dropper with rotating tip for cosmeceuticals

Quadpack_Freedom_Dropper

Quadpack's Freedom Dropper meets the growing demand for packaging solutions for cosmeceutical liquid formulations. 

Part dropper, part beauty accessory, part massage tool, this latest innovation from the packaging manufacturer's Creative Hub is based on its flagship glass solution, the 30ml Skin-Up bottle, which features a sleek, elegant shape and a rotating applicator to enhance the user experience.

"It's a completely innovative concept!explains Alejandra Isern, Category Specialist. Combining a dropper and a rotary applicator delivers exactly the value-added solution that luxury brands are looking for. It's a new experience for users, putting them in control. Unscrew the cap and apply a drop to your hand or directly to your face. Then spread it with the flexible rotating tip. Use it as a dropper or beauty accessory. You have the freedom to use it as you wish!"

Using the Freedom Dropper transforms product application into a beauty ritual. Housed in a familiar format with tried-and-tested features, it allows complete control of the formula. Drops are gradually distilled by exerting gentle pressure on the pipette, then applied to the skin using the rotating applicator. The soft-textured tip features a wave pattern inspired by the shapes of nature. Its rotating movement combined with the wavelets exerts a massaging effect by producing gentle vibrations, which activate the skin's circulation, facilitating absorption of the formula. It is also possible to develop a customized applicator at reduced cost, for example for brand personalization.

A specially designed wringer removes excess formula, ensuring that the stem and applicator remain impeccable, while delivering drops for a well-groomed experience.

Freedom Dropper was created for low-viscosity skincare and make-up products, and is particularly recommended for active-ingredient facial oils and moisturizing serums. The glass bottle enables it to be used with most formulas, even the most complex.

A multitude of decoration techniques can be applied to match the brand's identity. The thick-bottomed bottle is suitable for a range of finishes, from color gradients to holographic effects. The applicator stem and head can be injection-colored, while the nipple and collar can be glossy or matte. An aluminum ring can also be added to the collar.

Freedom Dropper is an example of Quadpack's avant-garde development approach. "We build on what works best and use components that have already proved their worth, such as the Skin-Up bottle. This allows us to create modular collections with speed and agility, while expanding their scope and functionality. In the case of Freedom Dropper, we're exploring new applicators to handle different types of formula, such as tinted make-up products. What you see today is just the beginning of an extremely exciting innovation".stresses Alejandra Isern.

The patent application is in progress.

YouTube video

Cosmetic science: shaping the future

SFC symposium

The 19th edition of the International Symposium "Cosmetic Science: Shaping the Future" organized by the Société française de Cosmétologie (SFC) will be held on December 2-3, 2025, in Paris and online. A wide range of topics will be addressed:

  • skin biology, applied to both skin and scalp,
  • microbiota, key players in maintaining skin balance,
  • the contributions of neuroscience and cognitive science,
  • innovative thinking, stimulated by open innovation,
  • high-potential new resources,
  • and disruptive tools, particularly those based on artificial intelligence.

This scientific event brings together researchers, scientists, manufacturers, startups, service providers and students.

A dynamic, fast-paced program, entirely in English, will feature keynotes (30-minute plenary lectures by international experts), scientific sessions (15-minute presentations, selected by a scientific jury for their relevance, innovative character and contribution to cosmetology) and interactive discussions.

A space for inspiration, meetings and exchanges, this year's symposium will adopt a hybrid format to reach a wider audience. In person, participants can attend at the Pathé Alésia cinema, 73 avenue du Général Leclerc, Paris 14th arrondissement. Remotely, via dedicated online access.

Another new feature is a redesigned sponsorship system designed to boost the visibility of partners and offer industry players a greater opportunity to highlight their commitment to the scientific and cosmetics community.

BDK Parfums: a collection of Mediterranean fragrances

Trio BDK Parfums x Edith Carron

A tribute to the flavors and scents of the Mediterranean, the Azur collection from BDK Parfums captures the spirit of travel and a promise of elsewhere. It's also the story of a meeting between David Benedek, founder of BDK Parfums, and illustrator Édith Carron.

For the second year running, the designer and the artist whose work has been published in The New Yorker Magazine and The New York Times are collaborating. This encounter between perfumery and illustration has given rise to an ephemeral collection of three fragrances. Édith Carron's colorful, graphic style adorns not only the cases, but also the labels of each fragrance. "In a fresh, watercolor style, she adds a strong cultural dimension to the evocation of the resort, calling up in turn the works of Pablo Picasso, Jean Giono and Jean-Luc Godard. Here, a piece of pottery from Vallauris, a page from a novel by Francis Scott Fitzgerald or Ernest Hemingway, and there, memories of the Villa Malaparte emerge in a splash of sunlight. Each fragrance translates in its own way the atmosphere of a place, its unique light, right down to the melody that might be heard there".says the brand.

The three fragrances in the collection are part of this vibrant, sensory tableau. Citrus Riviera's luminous notes of mandarin, lemon and tonka bean instantly transport you to the festive, indolent atmosphere of the Côte d'Azur, for sunbathing on the pontoon of the Cap d'Antibes hotel, in the maze of the Villa Maeght and even in Picasso's studio in Vallauris.

The three boxes of Citrus Riviera, Sel d'Argent and Villa Néroli form a single image, a 180° panorama of the Mediterranean, from dawn to sunset. This polychrome triptych - which will only last one summer - reinvents the Collection Azur.

Ralf Schwieger, Mane perfumer, Anne-Sophie Behaghel, Flair perfumer and Alexandra Carlin, formerly Symrise perfumer, are behind each of the three fragrances.

"The acidic freshness and citrus impression at the top are due to neroli essence, associated with Nerolione, very quickly relayed by orange blossom absolute. Its honeyed, straw-like facets echo Bulgarian rose absolute. In the base notes, a comforting impression of balms and resins, thanks to vanilla absolute and cistus labdanum, illustrate the moistness of the air and announce the trio of ambrox, moss and cashmeran to convey the salty minerality of Faraglioni. An olfactory tableau of this island symbol of beauty and refinement".explains Alexandra Carlin.

The limited editions of eaux de parfum BDK Parfums × Édith Caron from the Azur Collection are available from June 16, 2025 until September 2025 at the BDK Parfums boutique, in leading French independent perfumery boutiques, in selected international outlets and on bdkparfums.com.

Prod&Pack 2025: packaged goods take center stage

Prod&Pack

From November 18 to 20, 2025, the 3rd edition of Prod&Pack Eurexpo Lyon will be held for packaging, process and production professionals.

The program includes demonstrations and feedback on processes for optimizing production lines, integrating re-use solutions and anticipating regulatory changes.

The "Showroom": an immersive experience at the heart of five materials

Unprecedented in its design and located in a new hall, the "Showroom" will host five packaging lines representing the technologies of today and tomorrow. 

Wood, cardboard, metal, plastic and glass: five materials in particular will be highlighted, each with its own constraints.

Visitors will be able to discover innovative solutions capable of meeting the expectations of industrial performance and the requirements of reuse, recyclability and packaging reduction. 

A pitch zone will enable participants to present their solutions.

AMC2, Barcodis, Bfr Systems, Cgp Coating, Domino Equans Digital, Marquage, Dune, Faber, Guignard Robotisation, Ima, Massilly Services, Mecapack, Novexx, Pandobac, Rescaset, Robocc, Vif... have already confirmed their participation.

The "Pépinière", a space dedicated to emerging projects

A new space within Prod&Pack, the "Pépinière" will offer investors looking for bold, innovative projects the chance to meet startups and young companies that have developed products, solutions and concepts with high potential for the production, process and packaging industries.

The sustainable trends aisle

Adopted at the end of 2024, the European Packaging and Packaging Waste Regulation (PPWR) sets a number of targets, including reaching 70 % of recycling by 2025 and 75 % by 2030.

For companies looking for solutions, the Sustainable Trends Aisle will present the latest innovations in eco-design, labeling, traceability... 

Reuse in the spotlight

Since its creation in 2011, Prod&Pack has been at the heart of transformations in the packaging sector. In 2019, it will become the first show in France to make reuse a central focus of industrial challenges. With its new identity launching in 2021, Prod&Pack is fully asserting its mission: to anticipate future changes, propose concrete solutions and actively contribute to the transition towards a circular economy.

The Village du Réemploi will once again be showcased, in partnership with the Réseau Vrac et Réemploi. Some twenty companies will be showcasing their solutions for integrating efficient reusable models across the entire value chain: production, distribution and consumption.

Selected for their operational maturity and technical expertise, these companies will support visitors wishing to integrate reuse into their production chain, learn about new logistics models or develop their CSR strategies. Eternity Systems, Magicpallet, Mecapack, Options Solutions, Pandobac, Reempack and Uzaje are among those taking part.

Les Assises nationales du Réemploi: assessment and outlook

An exclusive event organized as part of Prod&Pack, the Assises nationales du Réemploi will provide an opportunity to take stock of the various initiatives undertaken by national institutions and companies. In addition to feedback and testimonials on the use and development of reuse in France, they will provide an initial assessment of :

- The operation led by Go!Réemploi, which aims to set up a national, mutualized reuse scheme for food packaging in supermarkets and hypermarkets, to reach 10 % of reused packaging, in France, by 2027, as set by the Agec law. Since June 2025, as part of the ReUse initiative, the eco-organization Citéo has been rolling out this operation to make reusable packaging available to consumers in four pilot regions (Hauts-de-France, Normandy, Brittany and Pays-de-la-Loire). 

- The ReCosm experiment. Co-led by We don't need road and Circul'R, the ReCosm coalition has set up two initiatives for the reuse of cosmetics packaging on the one hand, and perfume bottles on the other. They began in September 2024 and early 2025 respectively.

EcoBeautyScore: here we go!

EcoBeautyScore

EcoBeautyScore, the world's first scientific environmental rating system for cosmetics and skincare products, has been officially launched across Europe.

Pioneering beauty brands, including Eucerin, Garnier, L'Oréal Paris, Neutrogena, Nivea, Schauma and others, have begun publishing their scores in selected European markets, as well as in the UK.

Developed over three years by the non-profit EcoBeautyScore Association, in collaboration with over 70 companies and federations in the cosmetics and personal care sector, this rating system offers brands and distributors a clear, transparent and consistent tool for measuring and communicating the environmental footprint of their products.

Based on the European Product Environmental Footprint (PEF) methodology, the EcoBeautyScore assigns products a grade from A to E, according to their impact on soil, water and air throughout their life cycle.

European consumer spending on beauty and personal care products is expected to exceed $150 billion by 2025, with growing demand for more sustainable alternatives. Yet one in two European consumers remains skeptical of brands' ecological claims, suspecting that they do not accurately reflect products' true environmental impact.

It's against this backdrop that the EcoBeautyScore offers a response that's both practical and timely: a scientific yet accessible rating system that simplifies a complex reality. The rigorous evaluation process takes into account the environmental impact of a product over its entire life cycle - from the origin of ingredients and packaging materials to use and disposal by the consumer.

The EcoBeautyScore methodology and platform have been reviewed and validated by independent experts. Brands using this system will be subject to regular audits, conducted by an independent third-party organization.

Consumer demand for such transparency is already strong: in a global survey of over 9,000 people in China, the USA, France and Brazil, more than two-thirds said the EcoBeautyScore label inspires confidence, and a majority plan to take the score into account when making their purchases.

"EcoBeautyScore offers the beauty industry the transparency tool it has long lacked. For the first time, brands can communicate their environmental impact in a way that is scientific, consistent and understandable to consumers. Thanks to an easy-to-use rating platform, companies have access to a wealth of data on the environmental critical points of their products, making it accessible to all brands, whatever their level of expertise in sustainable development, says Jean-Baptiste Massignon, Managing Director of the EcoBeautyScore Association. It's encouraging to see the first pioneering companies publish their scores. This marks an important step towards greater openness and collective responsibility in the sector. We know it won't happen overnight, but this is how progress begins: with a common framework, candid data and a commitment to fostering more informed choices for the planet."

After years of development and testing, the EcoBeautyScore system is now up and running, with an initial launch in four product categories: shampoos, conditioners, shower gels and face care products. The system is open to all manufacturers of cosmetics and skincare products, with brands already committed and more expected in the coming months.

It is free to try out, with integration support for brands of all sizes. Launched first in Europe, it will gradually be extended to the rest of the world, with the aim of covering all beauty products.

"Assessing the environmental impact of a beauty product is an inherently complex process, traditionally requiring extensive expertise. What we've done with EcoBeautyScore is to translate this complexity into a rating platform that is both scientifically rigorous and easy to access, comments Laurent Gilbert, Scientific Director of EcoBeautyScore. Based on a methodology recognized by the European Commission as the most effective for measuring environmental footprints, the rating assesses products on 16 dimensions, including carbon emissions, water consumption and resource depletion. This level of detail enables brands and retailers to better identify areas for improvement, while offering consumers a simple, transparent score to guide more responsible choices. It's both technically demanding and simple to understand - and it's precisely this combination that makes it a powerful lever for driving the cosmetics industry forward."

Brands interested in a more transparent and sustainable approach can test the system free of charge. 

For more information: www.ecobeautyscore.com.

Exsymol's scientific innovation honored at the IFSCC 2025 World Congress in Cannes

Exsymol - IFSCC 2025

Exsymol will be taking part in this year's prestigious IFSCC (International Federation of Societies of Cosmetic Chemists) congress in Cannes, from September 15 to 18, 2025.

Among the hundreds of applications received by the scientific committee, four papers proposed by Exsymol have been selected:

  • 1 oral lecture on psychological stress,
  • 3 scientific posters on skinification, transcriptomics and silicon.

This selection is a major recognition of the quality and relevance of the work carried out by the Monegasque company's Innovation team.

A fine collective reward, which testifies to Exsymol's constant commitment to advancing science in the service of high-performance, safe and responsible cosmetics.

Stand n°43

Exsymol will also be present on stand 43 at the IFSCC exhibition. Visitors will have the opportunity to meet our teams, discuss our latest innovations and explore new avenues for scientific collaboration.

Äio biotech raises €1 million 

Äio - Nemailla Bonturi

Estonian start-up Äio, specializing in the development of sustainable animal-free fats and oils via advanced fermentation processes, has raised €1 million to accelerate the development of safer, more environmentally-friendly alternatives to oils traditionally used in cosmetics and chemicals. 

Founded in 2022 as a spin-off from Tallinn University of Technology, Äio uses biomass and precision fermentation to transform industrial by-products into nutrient-rich oils and fats. According to the company's data, this process requires 97 % less agricultural land and 90 % less water than traditional palm oil production. For the cosmetics industry, Äio's solutions offer an eco-responsible, high-performance and cost-effective alternative to palm and coconut oils, which are ubiquitous in personal care products. Thanks to their nourishing properties and additional bioactive benefits, these ingredients are a natural alternative to petroleum-based mineral oils, which are harmful to the skin and pollute the environment.

The €1 million funding comes in the form of a grant from Estonia's public Applied Research Program (RUP), coordinated by the Estonian Agency for Innovation and Economic Development (EIS). The grant will support a three-year R&D project focusing on lipids and derivatives derived from microbial fermentation, with a specific focus on applications in cosmetics and personal care. The total project budget is 1.8 million euros.

"This grant is more than just funding: it's recognition by the Estonian government that our technology can fundamentally transform the production of cosmetic ingredients, says Nemailla Bonturi, co-founder and CEO of Äio. We're now ready to roll out this impact on an international scale, offering smarter, more sustainable alternatives in an industry that touches everyone's daily lives. We look forward to commercializing our innovation and collaborating with forward-thinking beauty and skincare brands around the world."

"We actively support the development of Estonian innovations with strong global growth potential, capable of bringing real added value and responding to the major challenges of our time. Biotechnology and sustainable bio-based materials are among our strategic priorities, explains Ene Viiard, R&D expert with the RUP program. Competition for an OR grant is fierce, but in Äio's case we see an exceptional team, with the scientific knowledge and disruptive spirit capable of demonstrating that a small country like Estonia can produce innovations with global impact."

The timing of this grant coincides perfectly with major regulatory developments, notably the European regulation on deforestation, which will profoundly impact palm oil supply and accentuate demand for sustainable, traceable alternatives, within "future-ready" supply chains. Äio's yeast-based solutions provide a direct response to these challenges, with superior traceability and consistent quality, unlike agricultural ingredients subject to the vagaries of climate and geopolitics.

At the same time, the cosmetics industry is facing ever-tighter standards, notably with restrictions on PFAS and growing concerns about the risks to human health and the environment associated with microplastics. Fermentation-derived ingredients represent naturally "clean" alternatives, complying with regulatory requirements and consumers' expectations of transparency.

The ingredients developed by Äio are compatible with a wide range of cosmetic applications: everyday soaps, high-end moisturizers, serums and even make-up based on specialized pigments. This versatility positions Äio as a partner of choice, both for major international brands seeking large-scale sustainable supply chains, and for disruptive independent brands focusing on formulation innovation.

"The cosmetics industry is at a turning point. All brands, large and small, are realizing that sustainability is no longer a bonus, but an essential requirement driven by consumers, explains Magdalena Koziol, head of cosmetics development at Äio. Until recently, sustainable solutions have been hampered by performance or cost barriers to ingredients such as palm or coconut oil. Through research, development and rigorous scientific validation, we are demonstrating that ingredients derived from fermentation have immense commercial potential for a future where beauty, whether everyday or luxury, will no longer be at the expense of the planet or human health."

Äio is currently in active discussions with cosmetics manufacturers interested in integrating its ingredients into various formulations. The company has already begun sending samples to producers, in preparation for the next stage of its business development. A fund-raising round is planned by the end of the third quarter of 2026 to support its expansion. The alternative fats market is estimated to grow at 6 % per year, reaching $4.5 billion by 2032.

"We're seeing unprecedented interest from manufacturers, who understand that sustainable sourcing is no longer an option, continues Magdalena Koziol. We're ready to step up our efforts and are actively seeking partners to support us in our mission to create real change in the industry. The question is no longer whether the industry will switch to alternative ingredients, but how quickly. And the right time to act is now."

MakeUp in Paris: a record 15ᵉ edition

MakeUp in Paris

The 15ᵉ edition of MakeUp in Paris took place on June 18 and 19, 2025, bringing together 4,580 participants and recording an international participation rate of 30 %. 

This year's event brought together professionals from 59 countries, with a strong increase in participation from Scandinavian countries, notably Denmark and Sweden. Italy and South Korea broke attendance records, with an average increase of 80 % in the number of participants, closely followed by Spain and Portugal.

On the exhibitor side, the event welcomed 145 manufacturers and 14 trend agencies representing 19 countries. The largest delegations were from Italy, France and South Korea.

Other countries represented include Belgium, China, Germany, Hong Kong, Japan, Netherlands, Poland, Singapore, Spain, Sweden, Switzerland, Taiwan, Thailand, United Kingdom, United States and Vietnam.

As with every edition, MakeUp in Paris offered a program rich in content: 16 conferences and 12 workshops with 95 expert speakers.

The IT Awards were also very popular, with 65 exhibitors registering 116 products, broken down as follows:

  • Accessories: 4 products
  • Formulation: 64 products
  • Full Service: 21 products
  • Packaging: 27 products
  • Ocean Beauty (new cross-category): 23 products

The winners:

  • Futura - Avant Lab - Pennelli Faro, in the Accessories category
  • Non-Transfer Crystal-Watery Lipstick - A&H Cosmetics, in the Formulation category
  • Eco Formelt Multi-Pencil - Cosmax, in the Full service category 
  • SEamless Powder Tech - Ancorotti Group, in the Public Coup de Coeur category 
  • Cheeky Lipstick - La French Company & Cap Innovation in the Packaging category 
  • Waterburst Dazzle Top Coat - Gotha Cosmetics in the category Ocean Beauty

Amoéba signs an agreement with Metron Technology, a subsidiary of the Oriental Beauty Valley group

Amoéba

Amoéba, an industrial greentech specializing in the development of natural microbiological solutions based on the patented exploitation of amoebae, announces the signature of an agreement with Metron Technology, a subsidiary of the Chinese Oriental Beauty Valley group (OBV Group). This agreement confirms the main terms of the memorandum of understanding announced on April 1, 2025, and covers both the regulatory and commercial aspects of Amoéba's cosmetic ingredient in China.

The agreement provides for support and advice from the Oriental Beauty Valley group in obtaining approval for Amoéba's cosmetic ingredient in China, as well as priority for Metron Technology to distribute Amoéba's cosmetic ingredient in China once approval has been obtained.

Amoéba steps up development of its cosmetics business

While Amoéba's cosmetic ingredient was already included on the Inci list in 2024, enabling it to be marketed without further authorization worldwide with the exception of China, this agreement enables Amoéba to accelerate its entry into the Chinese market, the world's second-largest cosmetics market after the United States.

Following the arrival of Charlotte Franceries - a former member of L'Oréal's top management for 25 years and currently President of the McCann Group's French agency - to its Board of Directors, who will bring all her expertise and knowledge of the cosmetics industry, Amoéba has now taken a new step in the development of its cosmetics business.

"We are delighted to sign this agreement with the Oriental Beauty Valley (OBV) group, which is the ideal partner to support our development in China. While we have already achieved many key milestones in biocontrol this year, we are now accelerating the development of our cosmetics segment with players recognized worldwide for their expertise. We are proud that the full potential of our cosmetic ingredient has been recognized by the OBV group, a global reference player, and we are demonstrating our ability to pursue our ambitious development trajectory".said Benoît Villers, Chairman of Amoéba's Board of Directors.

The Oriental Beauty Valley group, based in Shanghai, is an industrial cluster supported by the Chinese authorities as part of their national development strategy for the cosmetics sector. It brings together over 1,000 companies (including L'Oréal, Shiseido etc.), laboratories, research centers and specialized organizations, forming an ecosystem that fosters synergies between innovation, production and regulation, and offers a structured environment to support innovative projects, from formulation to regulatory compliance.

Photo taken from the Amoéba website.

Cosm'ing 2025: an ethical approach essential for tomorrow's cosmetics 

Cosming June 2025
site-industries-cosmetiques A middle-aged woman with medium-length blond hair wears a dark blazer over a patterned blouse. She stands in front of a plain gray background and smiles slightly at the camera, as if ready to write her next idea in Auto Draft.
Delphine Pirot-Ayesse - Biotech Santé Bretagne

Faced with environmental and societal challenges, the world of cosmetics is turning a corner, with more and more players reviewing their practices to adopt more sustainable, transparent and fairer approaches. From June 11 to 13, Saint-Malo's Palais du Grand Large was the venue for Cosm'ing 2025, a must-attend event for over 25 years for experts in biotechnology-based cosmetic ingredients. Organized by Biotech Santé Bretagne, the event brought together professionals to share their latest advances. Their aim was to show how the synergy between nature, science and technological innovation can support the sector's transition to a more responsible future.

Ethics, the compass of progress in cosmetics?

The word "ethics" is increasingly becoming a pillar of cosmetics discourse. This is what Michèle Barbier, a researcher at the Inria Centre at the Université Côte d'Azur, emphasized at the start of her talk. In her view, adopting an ethical approach means above all taking a long-term view, where technological and scientific advances must benefit both society and the environment. This means meeting major challenges: preserving biodiversity, limiting the depletion of natural resources, and above all, striking a balance between innovation, preservation of the planet and society. In a field such as biotechnology, which is largely based on the exploitation of living organisms, sensitive questions arise: what place should be given to GMOs? What limits should be set to new genome-editing techniques? The same is true of emerging digital tools such as artificial intelligence and digital twins... What social acceptability should be given to all these new technologies?

Towards the optimization of bioproduction in cosmetics 

Cosm'ing 2025 showcased the very latest innovations in the bioproduction of cosmetic ingredients, thanks in particular to the many micro-organisms that have become cellular factories promoting the diversity of metabolic pathways. These include Saccharomyces cerevisiae Givaudan for the production of low-molecular-weight hyaluronic acid, and Lantana Bio for the production of anthocyanins. Mibelle Biochemistry has developed the biotechnological production of moss biomass, called mossCellTec. Last but not least, Roelmi HPC France's SeidoTech Lux process uses a strain of Lactiplantibacillus plantarum to produce a bioactive complex rich in polyphenols, polysaccharides, proteins and fibers.

New concepts are also emerging, such as Codif International's SKin-Biotech, in which the skin microbiota acts as a micro-factory for active ingredients via fermentation. Lallemand is demonstrating that marine bacteria and some present on human skin, such as Staphylococcus epidermidis, can coexist and interact to protect and regenerate the skin. Seppic relies on a bank of rare macroalgae, cultivated sustainably to enrich cosmetic formulations. Finally, STH Biotech exploits the hair roots of hemp, promising for their protective metabolites, particularly in anti-aging.

Plants and microbiota: holobionts at the heart of bio-inspired innovation

The holobiont approach places the plant in a dynamic, co-evolving ecosystem. Today, it is the inspiration for numerous innovations in plant biotechnology. Such is the case at Bioeurope, which has drawn inspiration from the fungus Pseudozyma flocculosa to develop a glycolipid active against Staphylococcus aureus, targeting sensitive skin. At Croda, they use a polysaccharide derived from coral microbiota, plexaurane, to protect skin against pollution. Last but not least, Greentech uses the fermentation of Gentiana lutea to regenerate the cutaneous holobionte of mature skin. 

Exosomes attack beauty 

Today, exosomes are at the heart of advanced dermocosmetic research. Naturally produced by cells to communicate with each other, these tiny extracellular vesicles are attracting growing interest for their ability to transport active molecules (proteins, RNA, lipids) directly to skin cells. Used as vectors for targeted ingredients, they promote skin regeneration, stimulate collagen production and enhance tissue repair. For example, Capacités is exploring the production of extracellular vesicles (EVs) from Chlorella, a promising freshwater microalga. EVerZom offers an innovative industrial platform dedicated to the production, engineering and characterization of exosomes, via a CDMO service (Contract Development and Manufacturing Organization). Finally, Vytrus Biotech has developed a pioneering strategy for isolating and characterizing exosomes from cell cultures of Centella asiatica and Curcuma longarich in peptides, with proven effects on skin and hair, through tests in vitro and clinical trials.

The new keys to scientific investigation 

Analysis techniques are evolving thanks to the convergence of "omics" approaches (genomics, proteomics, metabolomics...) and bioinformatics tools. At the Institut de Chimie Organique et Analytique d'Orléans, researchers are highlighting the growing interest of molecular networks to more rapidly identify bioactive compounds in complex mixtures. Phytox, in collaboration with the Rocher group, carries out guided fractionation of diatoms Cylindrotheca fusiformis and adopts the molecular network approach to reveal bioactive clusters. In addition, new tools such as the ExAdEx 3D tissue model or BioHive skin organoids offer advanced platforms for testing the efficacy, safety and repositioning of cosmetic actives in a more personalized approach.

What about artificial intelligence in cosmetics?

Although ethical issues are emerging, notably concerning the management of personal data and the transparency of algorithms, artificial intelligence (AI) is also profoundly transforming the cosmetics sector. In R&D, AI accelerates the discovery of active ingredients, optimizes formulations and predicts product efficacy. It also plays a key role in personalized skin diagnostics via mobile applications or connected tools, and in production, it improves manufacturing processes and traceability. It also helps reduce animal testing by simulating biological responses using predictive models. Artificial intelligence is thus becoming a major driver of innovation in cosmetics. As part of the European CYPher project, the Biomolecules Center at Ghent University is proposing a standardized production platform for terpenes and flavonoids, combining AI and synthetic biology. Other initiatives reinforce this trend towards using AI for greater performance. For example, MorphGen uses generative AI to design new copolymers, MeNow identifies bacterial bioactives via a structure-activity modeling platform, and Elysia Bioscience accelerates proteomic data processing with its ElyOm software. Finally, Cargill Beauty is exploring intelligent polymer mapping to develop more natural alternatives to petro-based polymers. AI thus paves the way for eco-designed, personalized and high-performance ingredients.

All the topics discussed at this symposium point to new promises of results in the more or less long term, which will certainly be highlighted at the next edition of Cosm'ing 2025, scheduled for June 30 to July 2, 2027!

Étonnants découvreurs" competition: science in stand-up mode!Developed in partnership with the GDR Cosm'actifs, this competition is aimed at doctoral students, whose mission is to present their thesis work in an original way, in 180 seconds. The 2025 prize was awarded to Morag Davidson, who completed her thesis in the LABCiS laboratory at the University of Limoges, on the eco-extraction of bioactive compounds from red fruit pomace. The aim is to develop an innovative extraction process based on the principles of green chemistry. In a single step, using a combination of enzymes, water and ultrasound, it produces bioactive compounds that reveal, via tests in vitroThese antioxidant and prebiotic properties are of great interest for cosmetic skincare products.

Delphine Pirot-Ayesse
Research and Market Watch Manager - Biotech Santé Bretagne

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